Palomid 529

TargetMol
Product Code: TAR-T2706
Supplier: TargetMol
CodeSizePrice
TAR-T2706-5mg5mg£108.00
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Quantity:
TAR-T2706-1mL1 mL * 10 mM (in DMSO)£112.00
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Quantity:
TAR-T2706-10mg10mg£125.00
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Quantity:
TAR-T2706-25mg25mg£177.00
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Quantity:
TAR-T2706-50mg50mg£269.00
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Quantity:
TAR-T2706-100mg100mg£399.00
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Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Further Information

Bioactivity:
Palomid 529 has been used in trials studying the treatment of Age-Related Macular Degeneration.
CAS:
914913-88-5
Formula:
C24H22O6
Molecular Weight:
406.434
Pathway:
Apoptosis; PI3K/Akt/mTOR signaling
Purity:
0.9903
SMILES:
COc1ccc(COc2cc3oc(=O)c4cc(ccc4c3cc2OC)C(C)O)cc1
Target:
Apoptosis; mTOR

References

1. Xue Q, et al. Cancer Res, 2008, 68(22), 9551-9557. 2. Diaz R, et al. Br J Cancer 2009, 100(6), 932-940. 3. Lewis GP, et al. Invest Ophthalmol Vis Sci, 2009, 50(9), 4429-4435. 4. Xiang T, et al. Oncogene, 2011, 30(21), 2443-2450. 5. Gravina GL, et al. Endocr Relat Cancer, 2011, 18(4), 385-400. 6. Weinberg MA, et al. RES-529: a PI3K/AKT/mTOR pathway inhibitor that dissociates the mTORC1 and mTORC2 complexes. Anticancer Drugs. 2016 Jul;27(6):475-87. 7. Zhou W, Lou W, Chen J, et al. AG-1024 Sensitizes Sorafenib-Resistant Hepatocellular Carcinoma Cells to Sorafenib via Enhancing G1/S Arrest[J]. OncoTargets and Therapy. 2021, 14: 1049-1059.