TargetMol

Avasimibe

Product Code:
 
TAR-T2753
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T2753-10mg10mg£105.00
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Quantity:
TAR-T2753-1mL1 mL * 10 mM (in DMSO)£109.00
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TAR-T2753-25mg25mg£136.00
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TAR-T2753-50mg50mg£189.00
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TAR-T2753-100mg100mg£282.00
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Quantity:
TAR-T2753-200mg200mg£412.00
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This product comes from: United States.
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Further Information

Bioactivity:
Avasimibe is an orally bioavailable inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT, IC50: 3.3 μM) that prevents cholesterol deposition in the arterial wall. It also inhibits human P450 isoenzymes CYP2C9/1A2/2C19 (IC50: 2.9/13.9/26.5 μM).
CAS:
166518-60-1
Formula:
C29H43NO4S
Molecular Weight:
501.73
Pathway:
Metabolism
Purity:
0.9991
SMILES:
CC(C)c1cc(C(C)C)c(CC(=O)NS(=O)(=O)Oc2c(cccc2C(C)C)C(C)C)c(c1)C(C)C
Target:
P45; Acyltransferase

References

1. Lee HT, et al. J Med Chem, 1996, 39(26), 5031-5034. 2. Ramharack R, et al. Atherosclerosis, 1998, 136(1), 79-87. 3. Wilcox LJ, et al. Arterioscler Thromb Vasc Biol, 1999, 19(4), 939-949. 4. Rodriguez A, et al. Atherosclerosis, 2002, 161(1), 45-54. 5. Sahi J, et al. Drug Metab Dispos. 2004, 32(12):1370-6.