TargetMol

Tripterin

Product Code:
 
TAR-T3028
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T3028-5mg5mg£107.00
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Quantity:
TAR-T3028-1mL1 mL * 10 mM (in DMSO)£115.00
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TAR-T3028-10mg10mg£128.00
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TAR-T3028-25mg25mg£151.00
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TAR-T3028-50mg50mg£172.00
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Quantity:
TAR-T3028-100mg100mg£208.00
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This product comes from: United States.
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Further Information

Bioactivity:
Celastrol is an effective proteasome inhibitor for the chymotrypsin-like activity of a purified 20S proteasome(IC50=2.5 μM) with antioxidant and anti-inflammatory activity.
CAS:
34157-83-0
Formula:
C29H38O4
Molecular Weight:
450.619
Pathway:
Autophagy; Ubiquitination; Apoptosis; Proteases/Proteasome
Purity:
0.999
SMILES:
CC1=C(O)C(=O)C=C2C1=CC=C1[C@@]2(C)CC[C@@]2(C)[C@@H]3C[C@@](C)(CC[C@]3(C)CC[C@]12C)C(O)=O
Target:
Apoptosis; Mitophagy; Proteasome; Autophagy

References

1. Yang H, et al. Cancer Res, 2006, 66(9), 4758-4765. 2. Allison AC, et al. Prog Neuropsychopharmacol Biol Psychiatry, 2001, 25(7), 1341-1357. 3. Sethi G, et al. Blood, 2007, 109(7), 2727-2735. 4. Kannaiyan R, et al. Apoptosis, 2011, 16(10), 1028-1041. 5. Liu Q, Yue Y, Wang S, et al. Celastrol Attenuates the Remodeling of Pulmonary Vascular and Right Ventricular in Monocrotaline-Induced Pulmonary Arterial Hypertension in Rats[J]. 2021 6. Jiang X, Chen S, Zhang Q, et al. Celastrol is a novel selective agonist of cannabinoid receptor 2 with anti-inflammatory and anti-fibrotic activity in a mouse model of systemic sclerosis[J]. Phytomedicine. 2019: 153160.