ALK-IN-1

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TargetMol
Product Code: TAR-T3059
Supplier: TargetMol
CodeSizePrice
TAR-T3059-2mg2mg£95.00
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TAR-T3059-5mg5mg£108.00
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TAR-T3059-1mL1 mL * 10 mM (in DMSO)£115.00
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Quantity:
TAR-T3059-10mg10mg£124.00
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Quantity:
TAR-T3059-25mg25mg£148.00
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Quantity:
TAR-T3059-50mg50mg£189.00
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Quantity:
TAR-T3059-100mg100mg£269.00
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TAR-T3059-200mg200mg£366.00
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TAR-T3059-500mg500mg£549.00
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Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
AP26113 is a potent ALK inhibitor with IC50 of 0.62 nM in a cell-free assay, demonstrated ability overcome Crizotinib resistance mediated by a L1196M mutation. Phase 2.
CAS:
1197958-12-5
Formula:
C26H34ClN6O2P
Molecular Weight:
529.02
Pathway:
Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
Purity:
0.9766
SMILES:
COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1)N1CCC(CC1)N(C)C
Target:
EGFR; IGF-1R; ALK

References

1. Wei-Sheng Huang, et al. J Med Chem, 2016, 59(10):4948-4964. 2. Uchibori K, et al. Nat Commun. 2017, 8:14768.