Niraparib

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TargetMol
Product Code: TAR-T3231
Supplier: TargetMol
CodeSizePrice
TAR-T3231-5mg5mg£115.00
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TAR-T3231-1mL1 mL * 10 mM (in DMSO)£119.00
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TAR-T3231-10mg10mg£135.00
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TAR-T3231-25mg25mg£166.00
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TAR-T3231-50mg50mg£189.00
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TAR-T3231-100mg100mg£254.00
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TAR-T3231-500mg500mg£531.00
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Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
MK-4827(Niraparib) is a selective inhibitor of PARP1/PARP2 with IC50 of 3.8 nM/2.1 nM; with great activity in cancer cells with mutant BRCA-1 and BRCA-2; >330-fold selective against PARP3, V-PARP and Tank1.
CAS:
1038915-60-4
Formula:
C19H20N4O
Molecular Weight:
320.396
Pathway:
Chromatin/Epigenetic; ; Apoptosis; DNA Damage/DNA Repair
Purity:
0.9991
SMILES:
NC(=O)c1cccc2cn(nc12)-c1ccc(cc1)[C@@H]1CCCNC1
Target:
Apoptosis; PARP

References

1. Wang L, et al. Invest New Drugs. 2012, 30(6):2113-20. 2. Jones P, et al. J Med Chem. 2009, 52(22):7170-85.