SZL P1-41

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TargetMol
Product Code: TAR-T3317
Supplier: TargetMol
CodeSizePrice
TAR-T3317-1mg1mg£95.00
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TAR-T3317-2mg2mg£104.00
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TAR-T3317-5mg5mg£125.00
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TAR-T3317-1mL1 mL * 10 mM (in DMSO)£132.00
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TAR-T3317-10mg10mg£157.00
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TAR-T3317-25mg25mg£229.00
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TAR-T3317-50mg50mg£349.00
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TAR-T3317-100mg100mg£543.00
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TAR-T3317-500mg500mg£1,058.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
SZL P1-41, a skp2 inhibitor, can prevent assembly of Skp2-Skp1 complexes. It selectively suppresses Skp2 SCF E3 ligase activity but exhibits no effect on the activity of other SCF complexes. It also inhibits Skp2-mediated p27 and Akt ubiquitination in vivo and in vitro. It suppresses the survival of Y cells and Y stem cells by triggering cell senescence and inhibiting glycolysis. It exhibits antitumor effects in multiple animal models and Y cell lines.
CAS:
222716-34-9
Formula:
C24H24N2O3S
Molecular Weight:
420.53
Pathway:
; Apoptosis; Ubiquitination
Purity:
0.9982
SMILES:
CCc1cc2c(occ(-c3nc4ccccc4s3)c2=O)c(CN2CCCCC2)c1O
Target:
Apoptosis; E1/E2/E3 Enzyme

References

Chan et al.Cell, 2013;154:556