Selonsertib

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TargetMol
Product Code: TAR-T3350
Supplier: TargetMol
CodeSizePrice
TAR-T3350-2mg2mg£107.00
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TAR-T3350-5mg5mg£128.00
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TAR-T3350-1mL1 mL * 10 mM (in DMSO)£133.00
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TAR-T3350-10mg10mg£145.00
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TAR-T3350-25mg25mg£198.00
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TAR-T3350-50mg50mg£233.00
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TAR-T3350-100mg100mg£362.00
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TAR-T3350-200mg200mg£490.00
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TAR-T3350-500mg500mg£751.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
Selonsertib is an orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with potential anti-inflammatory, antineoplastic and anti-fibrotic activities.
CAS:
1448428-04-3
Formula:
C24H24FN7O
Molecular Weight:
445.502
Pathway:
MAPK; Apoptosis
Purity:
0.9953
SMILES:
CC(C)n1cnnc1-c1cccc(NC(=O)c2cc(c(C)cc2F)-n2cnc(c2)C2CC2)n1
Target:
Apoptosis; ASK; MAPK

References

Yuan J, Yao C, Tang J, et al. Enhanced GRP78 protein expression via the IRE1?/ASK1/p38 MAPK pathway during As2O3-induced endoplasmic reticulum stress in BEAS-2B cells. Toxicology. 2021, 462: 152962. Lin JH, et al. Nephron. 2015, 129(1):29-33.