Icaritin

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TargetMol
Product Code: TAR-T3398
Supplier: TargetMol
CodeSizePrice
TAR-T3398-1mg1mg£95.00
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TAR-T3398-5mg5mg£121.00
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TAR-T3398-1mL1 mL * 10 mM (in DMSO)£125.00
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TAR-T3398-10mg10mg£164.00
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TAR-T3398-25mg25mg£229.00
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TAR-T3398-50mg50mg£306.00
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TAR-T3398-100mg100mg£422.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Further Information

Bioactivity:
Icaritin has hormone regulation activity and cardiovascular function improvement activity. Icaritin has anticancer activity, can induce S phase arrest and apoptosis, inhibit ENKL cell proliferation. Icaritin has anti-multiple myeloma activity, mainly mediated by inhibiting IL-6/JAK2/STAT3 signaling. Icaritin at low concentration (4 or 8 μMol/L) can promote rat chondrocyte proliferation and inhibit cell apoptosis, while the effect of Icaritin on rat chondrocyte at high concentration was reversed.
CAS:
118525-40-9
Formula:
C21H20O6
Molecular Weight:
368.385
Pathway:
Apoptosis; Angiogenesis; Stem Cells; Chromatin/Epigenetic; JAK/STAT signaling; Autophagy
Purity:
0.9896
SMILES:
COc1ccc(cc1)-c1oc2c(CC=C(C)C)c(O)cc(O)c2c(=O)c1O
Target:
Apoptosis; JAK; STAT; Autophagy

References

Gao Y, Xu G, Ma L, et al. Icarisid I specifically facilitates ATP or nigericin-induced NLRP3 inflammasome activation and causes idiosyncratic hepatotoxicity. Cell Communication and Signaling. 2020 Gao Y, Xu G, Ma L, et al. Icariside I specifically facilitates ATP or nigericin-induced NLRP3 inflammasome activation and causes idiosyncratic hepatotoxicity. Cell Communication and Signaling. 2021 Feb 11;19(1):13. doi: 10.1186/s12964-020-00647-1. Qin L, et al. Biomaterials. 2015 Aug;59:125-43. Gao Y, Xu G, Ma L, et al. Icarisid I specifically facilitates ATP or nigericin-induced NLRP3 inflammasome activation and causes idiosyncratic hepatotoxicity[J]. Cell Communication and Signaling. 2020 Liu YQ, et al. Phytomedicine. 2014 Oct 15;21(12):1633-7. Gao Y, Xu G, Ma L, et al. Icariside I specifically facilitates ATP or nigericin-induced NLRP3 inflammasome activation and causes idiosyncratic hepatotoxicity[J]. Cell Communication and Signaling. 2021, 19(1): 1-14. Zhu S, et al. Oncotarget. 2015 Apr 30;6(12):10460-72.