VER-49009

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TargetMol
Product Code: TAR-T3454
Supplier: TargetMol
CodeSizePrice
TAR-T3454-1mg1mg£106.00
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TAR-T3454-2mg2mg£122.00
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TAR-T3454-1mL1 mL * 10 mM (in DMSO)£136.00
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TAR-T3454-5mg5mg£148.00
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TAR-T3454-10mg10mg£195.00
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TAR-T3454-25mg25mg£294.00
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TAR-T3454-50mg50mg£436.00
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TAR-T3454-100mg100mg£570.00
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TAR-T3454-200mg200mg£777.00
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TAR-T3454-500mg500mg£1,099.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
VER-49009 is a potent Hsp90 inhibitor(IC50 of 25 nM and Kd of 78 nM).
CAS:
558640-51-0
Formula:
C19H18ClN3O4
Molecular Weight:
387.82
Pathway:
Cytoskeletal Signaling; Metabolism
Purity:
0.9993
SMILES:
CCNC(c([nH]nc1-c(c(O)c2)cc(Cl)c2O)c1-c(cc1)ccc1OC)=O
Target:
HSP

References

Sharp SY, et al. Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues. Mol Cancer Ther. 2007 Apr;6(4):1198-211. Sun X, et al. Inhibition of hepatic stellate cell proliferation by heat shock protein 90 inhibitors in vitro. Mol Cell Biochem. 2009 Oct;330(1-2):181-5. Dymock BW, et al. Novel, potent small-molecule inhibitors of the molecular chaperone Hsp90 discovered through structure-based design. J Med Chem. 2005 Jun 30;48(13):4212-5.