TargetMol

3-MATIDA

Product Code:
 
TAR-T3486
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T3486-1mg1mg£100.00
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TAR-T3486-2mg2mg£111.00
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TAR-T3486-1mL1 mL * 10 mM (in DMSO)£133.00
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TAR-T3486-5mg5mg£133.00
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TAR-T3486-10mg10mg£173.00
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TAR-T3486-25mg25mg£279.00
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TAR-T3486-50mg50mg£410.00
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TAR-T3486-100mg100mg£575.00
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TAR-T3486-500mg500mg£1,155.00
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Further Information

Bioactivity:
3-MATIDA is an effective mGluR-1 antagonist (IC50: 6.3 μM, rat mGluR-1a). Displays ? 40-fold selectivity over other receptors: mGluR-5, mGluR-2, mGluR-4 (mGluR-4a) (IC50 > 300 μM), NMDA and GluR (AMPA) (IC50 = 250 μM). 3-MATIDA act as a neuroprotectant in cultured murine cortical cells and rat hippocampal slice cultures in vitro.
CAS:
518357-51-2
Formula:
C8H9NO4S
Molecular Weight:
215.22
Pathway:
Neuroscience
Purity:
0.9841
SMILES:
Cc1cc(sc1C(N)C(O)=O)C(O)=O
Target:
GluR; NMDAR

References

Moroni, F., et al.The novel and systemically active metabotropic glutamate 1 (mGlu1) receptor antagonist 3-MATIDA reduces post-ischemic neuronal death.Neuropharmacology. 2002. Neuropharmacology. 42: 741-751. Cozzi, A., et al. 2002. Neuropharmacology. 43: 119-130.