TargetMol

RO8994

Product Code:
 
TAR-T3517
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T3517-1mg1mg£98.00
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TAR-T3517-2mg2mg£109.00
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TAR-T3517-5mg5mg£134.00
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TAR-T3517-1mL1 mL * 10 mM (in DMSO)£156.00
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TAR-T3517-10mg10mg£174.00
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TAR-T3517-25mg25mg£266.00
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TAR-T3517-50mg50mg£378.00
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TAR-T3517-100mg100mg£528.00
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Further Information

Bioactivity:
RO8994 is a highly effective and specific inhibitor of spiroindolinone small-molecule MDM2, with IC50 of 20 nM (MTT proliferation assays) and 5 nM (HTRF binding assays).
CAS:
1309684-94-3
Formula:
C31H31Cl2FN4O4
Molecular Weight:
613.51
Pathway:
Apoptosis; Ubiquitination
Purity:
0.9887
SMILES:
COc1cc(ccc1NC(=O)[C@@H]1N[C@@H](CC(C)(C)C)[C@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21)C(N)=O
Target:
Mdm2; E1/E2/E3 Enzyme; p53

References

Zhang Z,et al. Discovery of potent and selective spiroindolinone MDM2 inhibitor, RO8994, for cancer therapy. Bioorg Med Chem. 2014 Aug 1;22(15):4001-9.