Dichlorphenamide-13C6
| Code | Size | Price |
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| TAR-T36059-2mg | 2mg | £943.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
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Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Dichlorphenamide-13C6is intended for use as an internal standard for the quantification of dichlorphenamide by GC- or LC-MS. Dichlorphenamide is a sulfonamide and an orally bioavailable carbonic anhydrase (CA) inhibitor (Kis = 1.20, 38, 50, and 50 nM for the human CA isoforms CAI, CAII, CAIX, and CAXII, respectively).1It lowers intraocular pressure in rabbits when 50 μl of a 10% solution is applied topically to the eye.2Dichlorphenamide rescues the potassium deficiency and prevents insulin-induced paralysis in a rat model of familial hypokalemic periodic paralysis when administered at a dose of 5.6 mg/kg per day for ten days.3Formulations containing dichlorphenamide have been used in the treatment of glaucoma and primary periodic paralysis.
CAS:
1391054-76-4
Formula:
[13C]6H6Cl2N2O4S2
Molecular Weight:
311.1
Purity:
0.98
SMILES:
NS([13C]1=[13CH][13C](S(N)(=O)=O)=[13CH][13C](Cl)=[13C]1Cl)(=O)=O
References
Tricarico, D., Mele, A., and Conte Camerino, D.Carbonic anhydrase inhibitors ameliorate the symptoms of hypokalaemic periodic paralysis in rats by opening the muscular Ca2+-activated-K+ channelsNeuromuscul. Disord.16(1)39-45(2006)
Lotti, V.J., Schmitt, C.J., and Gautheron, P.D.Topical ocular hypotensive activity and ocular penetration of dichlorphenamide sodium in rabbitsGraefes Arch. Clin. Exp. Ophthalmol.222(1)13-19(1984)
Brzozowski, Z., Slawi?ski, J., Innocenti, A., et al.Carbonic anhydrase inhibitors. Regioselective synthesis of novel 1-substituted 1,4-dihydro-4-oxo-3-pyridinesulfonamides and their inhibition of the human cytosolic isozymes I and II and transmembrane cancer-associated isozymes IX and XIIEur. J. Med. Chem.45(9)3656-3661(2010)