GW4869

TargetMol
Product Code: TAR-T3640
Supplier: TargetMol
CodeSizePrice
TAR-T3640-2mg2mg£130.00
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TAR-T3640-5mg5mg£148.00
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TAR-T3640-10mg10mg£217.00
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TAR-T3640-25mg25mg£377.00
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Quantity:
TAR-T3640-50mg50mg£532.00
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Quantity:
TAR-T3640-100mg100mg£627.00
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Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

1 / 1

Further Information

Bioactivity:
GW4869 is a noncompetitive inhibitor of neutral sphingomyelinase (N-SMase, IC50 of 1 μM). GW4869 is an exosome biogenesis/release inhibitor.
CAS:
6823-69-4
Formula:
C30H30Cl2N6O2
Molecular Weight:
577.51
Pathway:
Metabolism
Purity:
0.9847
SMILES:
Cl.Cl.O=C(Nc1ccc(cc1)C1=NCCN1)C=Cc1ccc(C=CC(=O)Nc2ccc(cc2)C2=NCCN2)cc1
Target:
Phospholipase

References

Cao Z, Li P, Li Y, et al.Encapsulation of Nano?Bortezomib in Apoptotic Stem Cell?Derived Vesicles for the Treatment of Multiple Myeloma.Small.2023: 2301748. Han X, de Dieu Habimana J, Li A L, et al. Transcription factor EB-mediated mesenchymal stem cell therapy induces autophagy and alleviates spinocerebellar ataxia type 3 defects in neuronal cells model. Cell death & disease. 2022, 13(7): 1-12. Essandoh K, et al. Blockade of exosome generation with GW4869 dampens the sepsis-induced inflammation and cardiac dysfunction. Biochim Biophys Acta. 2015 Nov;1852(11):2362-71. Shi F, Deng Z, Zhou Z, et al. Heat injured stromal cells?derived exosomal EGFR enhances prostatic wound healing after thulium laser resection through EMT and NF??B signaling. The Prostate. 2019 May 24 Han C, Xia X, Jiao S, et al. Tripartite motif containing protein 37 involves in thrombin stimulated BV-2 microglial cell apoptosis and interleukin 1? release[J]. Biochemical and biophysical research communications. 2019, 516(4): 1252-1257. Ge M, Qiao Z, Kong Y, et al. Exosomes mediate intercellular transfer of non-autonomous tolerance to proteasome inhibitors in mixed-lineage leukemia. Cancer Science. 2020 Ge M, Qiao Z, Kong Y, et al. Exosomes mediate intercellular transfer of non?autonomous tolerance to proteasome inhibitors in mixed?lineage leukemia[J]. Cancer Science. 2020, 111(4): 1279. . Heat injured stromal cells?derived exosomal EGFR enhances prostatic wound healing after thulium laser resection through EMT and NF??B signaling. The Prostate. 2019 May 24. Luberto C, et al. Inhibition of tumor necrosis factor-induced cell death in MCF7 by a novel inhibitor of neutralsphingomyelinase. J Biol Chem. 2002 Oct 25;277(43):41128-39. Wang X, Chen Q Z, Zan Y X, et al.?. Exosomal miR?145?5p derived from orthohantavirus?infected endothelial cells inhibits HTNV infection. The FASEB Journal. 2020, 34(10): 13809-13825. Ge M, Qiao Z, Kong Y, et al. Exosomes mediate intercellular transfer of non-autonomous tolerance to proteasome inhibitors in mixed-lineage leukemia[J]. Cancer Science. 2020. Han C, Xia X, Jiao S, et al. Tripartite motif containing protein 37 involves in thrombin stimulated BV-2 microglial cell apoptosis and interleukin 1? release. Biochemical and biophysical research communications. 2019, 516(4): 1252-1257. Wang X, Chen Q Z, Zan Y X, et al.? Exosomal miR?145?5p derived from orthohantavirus?infected endothelial cells inhibits HTNV infection. The FASEB Journal. 2020, 34(10): 13809-13825.