TargetMol

Neoandrographolide

Product Code:
 
TAR-T3884
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T3884-1mg1mg£128.00
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TAR-T3884-5mg5mg£206.00
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TAR-T3884-1mL1 mL * 10 mM (in DMSO)£220.00
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TAR-T3884-10mg10mg£287.00
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TAR-T3884-25mg25mg£439.00
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TAR-T3884-50mg50mg£611.00
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TAR-T3884-100mg100mg£840.00
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TAR-T3884-500mg500mg£1,621.00
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This product comes from: United States.
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Further Information

Bioactivity:
Neoandrographolide has potent hypolipidemic effect and protects the cardiovascular without significant liver damage.Neoandrographolide has anti-inflammatory effect, might result from inhibition of iNOS and COX-2 expression through inhibiting p38 MAPKs activation.Neoandrographolide as chemosensitizer in S-Jurkat and X chromosome-linked inhibitor of apoptosis protein (XIAP)-overexpressing Jurkat cells, a model for chemoresistance.
CAS:
27215-14-1
Formula:
C26H40O8
Molecular Weight:
480.598
Pathway:
Neuroscience; Immunology/Inflammation
Purity:
0.999
SMILES:
C[C@@]1(CO[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)CCC[C@@]2(C)[C@H](CCC3=CCOC3=O)C(=C)CC[C@H]12
Target:
NOS; COX

References

Jiang H, Chen J, Li X, et al.Systematic identification of chemical components in Fufang Shuanghua oral liquid and screening of potential active components against SARS-CoV-2 protease.Journal of Pharmaceutical and Biomedical Analysis.2023, 223: 115118. Yang T,et al. Hypolipidemic effects of andrographolide and neoandrographolide in mice and rats. Phytother Res. 2013 Apr;27(4):618-23. Zhang J, Sun Y, Zhong L Y, et al. Structure-based discovery of neoandrographolide as a novel inhibitor of Rab5 to suppress cancer growth. Computational and Structural Biotechnology Journal. 2020, 18: 3936-3946. Zhang J, Sun Y, Zhong L Y, et al. Structure-based discovery of neoandrographolide as a novel inhibitor of Rab5 to suppress cancer growth[J]. Computational and Structural Biotechnology Journal. 2020, 18: 3936-3946. Pfisterer PH,et al. Neoandrographolide from Andrographis paniculata as a potential natural chemosensitizer. Planta Med. 2010 Oct;76(15):1698-700. Jiang H, Chen J, Li X, et al. Systematic Identification of Chemical Components in Fufang Shuanghua Oral Liquid and Screening of Potential Active Components Against SA? n Protease. Journal of Pharmaceutical and Biomedical Analysis. 2022: 115118.