TargetMol

CZC-54252 hydrochloride

Product Code:
 
TAR-T39202
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T39202-1mg1mg£102.00
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TAR-T39202-2mg2mg£115.00
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TAR-T39202-5mg5mg£144.00
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TAR-T39202-1mL1 mL * 10 mM (in DMSO)£166.00
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TAR-T39202-10mg10mg£185.00
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TAR-T39202-25mg25mg£295.00
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TAR-T39202-50mg50mg£470.00
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TAR-T39202-100mg100mg£655.00
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Further Information

Bioactivity:
CZC-54252 hydrochloride is a selective inhibitor of LRRK2 with IC50s of 1.85 nM and 1.28 nM for wild-type and G2019S LRRK2. CZC-54252 hydrochloride has a neuroprotective activity and attenuates G2019S LRRK2-induced human neuronal injury with an EC50 of 1 nM.
CAS:
1784253-05-9
Formula:
C22H26Cl2N6O4S
Molecular Weight:
541.45
Pathway:
Autophagy
Purity:
0.9821
SMILES:
Cl.O=S(=O)(NC=1C=CC=CC1NC2=NC(=NC=C2Cl)NC3=CC=C(C=C3OC)N4CCOCC4)C
Target:
LRRK2

References

Nigel Ramsden, et al. Chemoproteomics-based design of potent LRRK2-selective lead compounds that attenuate Parkinson's disease-related toxicity in human neurons. ACS Chem Biol. 2011 Oct 21;6(10):1021-8. Ramsden N, et al. Chemoproteomics-based design of potent LRRK2-selective lead compounds that attenuate Parkinson's disease-related toxicity in human neurons. ACS Chem Biol. 2011 Oct 21;6(10):1021-8.