LYN-1604

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TargetMol
Product Code: TAR-T4123
Supplier: TargetMol
CodeSizePrice
TAR-T4123-1mg1mg£139.00
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TAR-T4123-2mg2mg£169.00
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TAR-T4123-5mg5mg£250.00
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TAR-T4123-1mL1 mL * 10 mM (in DMSO)£346.00
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TAR-T4123-10mg10mg£346.00
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TAR-T4123-25mg25mg£536.00
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TAR-T4123-50mg50mg£736.00
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TAR-T4123-100mg100mg£994.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
LYN-1604 is a novel activator of ULK1, inducing cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis.
CAS:
2088939-99-3
Formula:
C33H43Cl2N3O2
Molecular Weight:
584.63
Pathway:
Apoptosis; Autophagy
Purity:
0.98
SMILES:
CC(C)CN(CC(=O)N1CCN(CC(c2ccc(Cl)cc2Cl)OCc2ccc3ccccc3c2)CC1)CC(C)C.Cl.Cl
Target:
Apoptosis; Autophagy

References

Zhang L, Fu L, Zhang S, Zhang J, Zhao Y, Zheng Y, He G, Yang S, Ouyang L, Liu B. Discovery of a small molecule targeting ULK1-modulated cell death of triple negative breast cancer in vitro and in vivo. Chem Sci. 2017 Apr 1;8(4):2687-2701. Ouyang L, Zhang L, Fu L, Liu B. A small-molecule activator induces ULK1-modulating autophagy-associated cell death in triple negative breast cancer. Autophagy. 2017 Apr 3;13(4):777-778.