PCI 29732

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TargetMol
Product Code: TAR-T4337
Supplier: TargetMol
CodeSizePrice
TAR-T4337-1mg1mg£98.00
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TAR-T4337-2mg2mg£109.00
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TAR-T4337-5mg5mg£135.00
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TAR-T4337-1mL1 mL * 10 mM (in DMSO)£142.00
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TAR-T4337-10mg10mg£173.00
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TAR-T4337-25mg25mg£273.00
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TAR-T4337-50mg50mg£431.00
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TAR-T4337-100mg100mg£600.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
PCI 29732 is a selective and irreversible Btk inhibitor with IC50 of 8.2 nM in a FRET based biochemical enzymology assay.
CAS:
330786-25-9
Formula:
C22H21N5O
Molecular Weight:
371.444
Pathway:
Tyrosine Kinase/Adaptors; Angiogenesis; Membrane transporter/Ion channel;
Purity:
0.9979
SMILES:
Nc1ncnc2n(nc(-c3ccc(Oc4ccccc4)cc3)c12)C1CCCC1
Target:
BCRP; BTK

References

Pan Z, etal. Discovery of selective irreversible inhibitors for Bruton's tyrosine kinase. ChemMedChem. 2007 Jan;2(1):58-61. Honigberg LA, etal. The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy. Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):13075-80.