KPT9274

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TargetMol
Product Code: TAR-T4354
Supplier: TargetMol
CodeSizePrice
TAR-T4354-1mg1mg£131.00
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TAR-T4354-2mg2mg£157.00
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TAR-T4354-5mg5mg£217.00
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TAR-T4354-1mL1 mL * 10 mM (in DMSO)£268.00
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TAR-T4354-10mg10mg£304.00
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TAR-T4354-25mg25mg£538.00
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TAR-T4354-50mg50mg£740.00
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TAR-T4354-100mg100mg£994.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
KPT-9274 is a non-competitive dual inhibitor of PAK4 and NAMPT(IC50= ~120 nM). It is an orally bioavailable small molecule.
CAS:
1643913-93-2
Formula:
C35H29F3N4O3
Molecular Weight:
610.637
Pathway:
Cytoskeletal Signaling; Metabolism
Purity:
0.9993
SMILES:
Nc1ccc(C=CC(=O)NCc2cc3cc(cc(-c4ccc(F)cc4)c3o2)-c2ccc(cc2)C(=O)N2CCC(F)(F)CC2)cn1
Target:
NAMPT; PAK

References

Abu Aboud O,etal.Dual and Specific Inhibition of NAMPT and PAK4 By KPT-9274 Decreases Kidney Cancer Growth.Mol Cancer Ther. 2016 Sep;15(9):2119-29.