Cycloguanil hydrochloride

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TargetMol
Product Code: TAR-T5420
Supplier: TargetMol
CodeSizePrice
TAR-T5420-1mg1mg£99.00
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TAR-T5420-2mg2mg£111.00
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TAR-T5420-5mg5mg£132.00
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TAR-T5420-1mL1 mL * 10 mM (in DMSO)£166.00
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TAR-T5420-10mg10mg£172.00
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TAR-T5420-25mg25mg£237.00
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TAR-T5420-50mg50mg£367.00
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TAR-T5420-100mg100mg£511.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
Cycloguanil is an active metabolite of the antimalarial compound proguanil. It acts as an inhibitor of dihydrofolate reductase (Kis: 0.3 and 1.5 nM for Plasmodium and human forms, respectively).
CAS:
152-53-4
Formula:
C11H15Cl2N5
Molecular Weight:
288.18
Pathway:
Metabolism; Microbiology/Virology
Purity:
0.9946
SMILES:
Cl.CC1(C)N=C(N)N=C(N)N1c1ccc(Cl)cc1
Target:
Parasite; Drug Metabolite

References

Wright JD, et al. The role of S-mephenytoin hydroxylase (CYP2C19) in the metabolism of the antimalarial biguanides. Br J Clin Pharmacol. 1995 Apr;39(4):441-4. Yuvaniyama J, et al. Insights into antifolate resistance from malarial DHFR-TS structures. Nat Struct Biol. 2003 May;10(5):357-65.