Dbet57

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TargetMol
Product Code: TAR-T5440
Supplier: TargetMol
CodeSizePrice
TAR-T5440-1mg1mg£109.00
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TAR-T5440-2mg2mg£124.00
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TAR-T5440-5mg5mg£168.00
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Quantity:
TAR-T5440-1mL1 mL * 10 mM (in DMSO)£213.00
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Quantity:
TAR-T5440-10mg10mg£222.00
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Quantity:
TAR-T5440-25mg25mg£306.00
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Quantity:
TAR-T5440-50mg50mg£436.00
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TAR-T5440-100mg100mg£610.00
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Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
dBET57 is heterobifunctional degrader of BRD4 based on the PROTAC technology, exhibits significant degradation of BRD4BD1 with a DC50/5h of 500 nM ,and inactive on BRD4BD2
CAS:
1883863-52-2
Formula:
C34H31ClN8O5S
Molecular Weight:
699.18
Pathway:
Chromatin/Epigenetic
Purity:
0.9952
SMILES:
Cc1nnc2[C@H](CC(=O)NCCNc3cccc4C(=O)N(C5CCC(=O)NC5=O)C(=O)c34)N=C(c3c(C)c(C)sc3-n12)c1ccc(Cl)cc1
Target:
Epigenetic Reader Domain

References

Nowak RP, et al. Plasticity in binding confers selectivity in ligand-induced protein degradation. Nat Chem Biol. 2018 Jul;14(7):706-714.