Rigosertib sodium

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TargetMol
Product Code: TAR-T5818
Supplier: TargetMol
CodeSizePrice
TAR-T5818-2mg2mg£98.00
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TAR-T5818-5mg5mg£115.00
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TAR-T5818-1mL1 mL * 10 mM (in DMSO)£117.00
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TAR-T5818-10mg10mg£142.00
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TAR-T5818-25mg25mg£189.00
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TAR-T5818-50mg50mg£262.00
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TAR-T5818-100mg100mg£389.00
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Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
Rigosertib, a non-ATP-competitive inhibitor of PLK1(IC50=9 nM), exhibits 30-fold higher specificity activity over Plk2 and no effect on Plk3.
CAS:
592542-60-4
Formula:
C21H24NNaO8S
Molecular Weight:
473.47
Pathway:
Cell Cycle/Checkpoint; PI3K/Akt/mTOR signaling; Apoptosis
Purity:
0.9937
SMILES:
COc1c(cc(cc1)CS(=O)(=O)/C=C/c1c(cc(cc1OC)OC)OC)NCC(=O)[O-].[Na+]
Target:
Apoptosis; PLK; PI3K

References

Chapman CM, et al. Clin Cancer Res, 2012 18(7), 1979-1991. Gumireddy K, et al. Cancer Cell, 2005, 7(3), 275-286. Reddy MV, et al. J Med Chem, 2011, 54(18), 6254-6276.