TargetMol

BV02

Product Code:
 
TAR-T60081
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T60081-1mg1mg£99.00
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TAR-T60081-2mg2mg£112.00
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TAR-T60081-5mg5mg£138.00
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TAR-T60081-1mL1 mL * 10 mM (in DMSO)£146.00
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TAR-T60081-10mg10mg£173.00
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TAR-T60081-25mg25mg£303.00
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TAR-T60081-50mg50mg£436.00
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TAR-T60081-100mg100mg£610.00
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TAR-T60081-500mg500mg£1,219.00
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Further Information

Bioactivity:
BV02 is an inhibitor of 14-3-3 protein-protein interactions and can be used in studies about the treatment of chronic myeloid leukemia. BV02 disrupts hematopoietic cells expressing the IM-resistant T315I mutation and the IM-sensitive wild-type Bcr-Abl.
CAS:
292870-53-2
Formula:
C20H15N3O5
Molecular Weight:
377.35
Purity:
0.9979
SMILES:
O=C(O)C1=CC=C2C(=O)N(C(=O)C2=C1)C=3C(=O)N(C=4C=CC=CC4)N(C3C)C

References

Mancini M, et al. A new nonpeptidic inhibitor of 14-3-3 induces apoptotic cell death in chronic myeloid leukemia sensitive or resistant to imatinib. J Pharmacol Exp Ther. 2011 Mar;336(3):596-604. Valensin D, et al. Molecular insights to the bioactive form of BV02, a reference inhibitor of 14-3-3? protein-protein interactions. Bioorg Med Chem Lett. 2016 Feb 1;26(3):894-898.