FRAX597

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TargetMol
Product Code: TAR-T6014
Supplier: TargetMol
CodeSizePrice
TAR-T6014-1mg1mg£98.00
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TAR-T6014-2mg2mg£109.00
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TAR-T6014-5mg5mg£135.00
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TAR-T6014-1mL1 mL * 10 mM (in DMSO)£149.00
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TAR-T6014-10mg10mg£182.00
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TAR-T6014-25mg25mg£273.00
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TAR-T6014-50mg50mg£405.00
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TAR-T6014-100mg100mg£568.00
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TAR-T6014-500mg500mg£1,139.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
FRAX597 is an effective, ATP-competitive inhibitor of group I PAKs, and for PAK1(IC50=8 nM), PAK2(IC50=13 nM), and PAK3 (IC50=19 nM).
CAS:
1286739-19-2
Formula:
C29H28ClN7OS
Molecular Weight:
558.1
Pathway:
Cytoskeletal Signaling
Purity:
0.9994
SMILES:
CCn1c2nc(Nc3ccc(cc3)N3CCN(C)CC3)ncc2cc(-c2ccc(cc2Cl)-c2cncs2)c1=O
Target:
PAK

References

Chow HY, et al. Cancer Res. 2012, 72(22), 5966-5975. Licciulli S, et al. J Biol Chem. 2013, 288(4), 29105-29114. Chow HY, et al. Oncotarget. 2015, 6(4), 1981-1994.