E-64
Code | Size | Price |
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TAR-T6037-5mg | 5mg | £107.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T6037-1mL | 1 mL * 10 mM (in DMSO) | £108.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T6037-10mg | 10mg | £128.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T6037-25mg | 25mg | £185.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T6037-50mg | 50mg | £273.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T6037-100mg | 100mg | £426.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T6037-500mg | 500mg | £867.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
E-64 is an irreversible and specific cysteine protease inhibitor. The IC50 of E-64 for papain is 9 nM.
CAS:
66701-25-5
Formula:
C15H27N5O5
Molecular Weight:
357.411
Pathway:
Autophagy; Microbiology/Virology; Proteases/Proteasome
Purity:
0.9995
SMILES:
CC(C)C[C@H](NC(=O)[C@@H]1O[C@H]1C(O)=O)C(=O)NCCCCNC(N)=N
Target:
Cysteine Protease; Antibacterial; Autophagy
References
Zhang B, Chen Z. Screening of cathepsin B inhibitors in traditional Chinese medicine by capillary electrophoresis with immobilized enzyme microreactor. Journal of Pharmaceutical and Biomedical Analysis. 2019: 112811
Jiang T Y, Pan Y F, Wan Z H, et al. PTEN status determines chemosensitivity to proteasome inhibition in cholangiocarcinoma[J]. Science Translational Medicine. 2020, 12(562).
Matsumoto K, et al. Biopolymers. 1999, 51(1), 99-107.
Zhang B, Chen Z. Screening of cathepsin B inhibitors in traditional Chinese medicine by capillary electrophoresis with immobilized enzyme microreactor[J]. Journal of Pharmaceutical and Biomedical Analysis. 2019: 112811.
Min SH, et al. J Reprod Dev. 2014, 60(1), 21-27.
Jiang T Y, Pan Y F, Wan Z H, et al. PTEN status determines chemosensitivity to proteasome inhibition in cholangiocarcinoma. Science Translational Medicine. 2020, 12(562).
Kobayashi H, et al. Cancer Res. 1992, 52(13), 3610-3614.
Guan X N, Zhang T, Yang T, et al. Covalent Sortase A Inhibitor ML346 Prevents Staphylococcus aureus Infection of Galleria mellonella. RSC Medicinal Chemistry. 2022
Hussein EM, et al. J Egypt Soc Parasitol. 2009, 39(1), 111-119.
Blass G, et al. Chronic cathepsin inhibition by E-64 in Dahl salt-sensitive rats. Physiol Rep. 2016 Sep;4(17). pii: e12950.
Barrett AJ, et al. Biochem J. 1982, 201(1), 189-198.