Sapitinib

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TargetMol
Product Code: TAR-T6092
Supplier: TargetMol
CodeSizePrice
TAR-T6092-2mg2mg£96.00
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TAR-T6092-5mg5mg£112.00
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TAR-T6092-1mL1 mL * 10 mM (in DMSO)£114.00
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TAR-T6092-10mg10mg£134.00
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TAR-T6092-25mg25mg£161.00
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TAR-T6092-50mg50mg£206.00
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TAR-T6092-100mg100mg£273.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
AZD8931, a reversible, ATP competitive inhibitor of EGFR(IC50=4 nM), ErbB2(IC50=3 nM) and ErbB3(IC50=4 nM), is more effective over Gefitinib or Lapatinib against NSCLC cell, 100-fold more specific for the ErbB family over MNK1 and Flt.
CAS:
848942-61-0
Formula:
C23H25ClFN5O3
Molecular Weight:
473.93
Pathway:
Angiogenesis; Tyrosine Kinase/Adaptors; JAK/STAT signaling
Purity:
0.9983
SMILES:
CNC(=O)CN1CCC(CC1)Oc1cc2c(Nc3cccc(Cl)c3F)ncnc2cc1OC
Target:
EGFR

References

Hickinson DM, et al. Clin Cancer Res, 2010, 16(4), 1159-1169.