Fostamatinib

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TargetMol
Product Code: TAR-T6115
Supplier: TargetMol
CodeSizePrice
TAR-T6115-1mg1mg£99.00
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TAR-T6115-2mg2mg£112.00
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TAR-T6115-5mg5mg£136.00
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TAR-T6115-1mL1 mL * 10 mM (in DMSO)£153.00
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TAR-T6115-10mg10mg£167.00
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TAR-T6115-25mg25mg£247.00
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TAR-T6115-50mg50mg£354.00
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TAR-T6115-100mg100mg£534.00
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TAR-T6115-500mg500mg£1,083.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
Fostamatinib(IC50 of 41 nM), which is a prodrug of the active metabolite R406, is a Syk inhibitor. It does not work on Lyn.
CAS:
901119-35-5
Formula:
C23H26FN6O9P
Molecular Weight:
580.466
Pathway:
Tyrosine Kinase/Adaptors; Membrane transporter/Ion channel; Neuroscience; GPCR/G Protein; Angiogenesis
Purity:
0.983
SMILES:
COc1cc(Nc2ncc(F)c(Nc3ccc4OC(C)(C)C(=O)N(COP(O)(O)=O)c4n3)n2)cc(OC)c1OC
Target:
FLT; Syk; Monoamine Transporter; Adenosine Receptor

References

Suljagic M, et al. Blood, 2010, 116(23), 4894-4905. Chen L et al.Blood, 2008, 111(4), 2230-2237. Bajpai M. IDrugs, 2009, 12(3), 174-185. Braselmann S, et al. J Pharmacol Exp Ther, 2006, 319(3), 1998-12008.