Pralatrexate

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TargetMol
Product Code: TAR-T6120
Supplier: TargetMol
CodeSizePrice
TAR-T6120-1mg1mg£95.00
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TAR-T6120-2mg2mg£106.00
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TAR-T6120-5mg5mg£125.00
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TAR-T6120-1mL1 mL * 10 mM (in DMSO)£128.00
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TAR-T6120-10mg10mg£164.00
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TAR-T6120-25mg25mg£209.00
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TAR-T6120-50mg50mg£237.00
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TAR-T6120-100mg100mg£367.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
Pralatrexate is a folate analogue inhibitor of dihydrofolate reductase (DHFR) exhibiting high affinity for reduced folate carrier-1 (RFC-1) with antineoplastic and immunosuppressive activities.
CAS:
146464-95-1
Formula:
C23H23N7O5
Molecular Weight:
477.481
Pathway:
Tyrosine Kinase/Adaptors; DNA Damage/DNA Repair; Metabolism; Cell Cycle/Checkpoint; Apoptosis
Purity:
0.9812
SMILES:
Nc1nc(N)c2nc(CC(CC#C)c3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)cnc2n1
Target:
Apoptosis; DHFR; Antifolate; TAM Receptor

References

Marchi E, et al. Clin Cancer Res, 2010, 16(14), 3648-3658. Molina JR, et al. IDrugs, 2008, 11(7), 508-521. Visentin M, et al. Cancer Chemother Pharmacol, 2013, 72(3), 597-606. Izbicka E, et al. Cancer Chemother Pharmacol, 2009, 64(5), 993-999.