Semagacestat

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TargetMol
Product Code: TAR-T6125
Supplier: TargetMol
CodeSizePrice
TAR-T6125-2mg2mg£98.00
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Quantity:
TAR-T6125-1mL1 mL * 10 mM (in DMSO)£106.00
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Quantity:
TAR-T6125-5mg5mg£115.00
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Quantity:
TAR-T6125-10mg10mg£155.00
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Quantity:
TAR-T6125-25mg25mg£230.00
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Quantity:
TAR-T6125-50mg50mg£367.00
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Quantity:
TAR-T6125-100mg100mg£511.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
Semagacestat (LY450139) is a γ-secretase blocker for Aβ42/Aβ40/Aβ38 (IC50: 10.9/12.1/12.0 nM) and also inhibits Notch signaling (IC50: 14.1 nM).
CAS:
425386-60-3
Formula:
C19H27N3O4
Molecular Weight:
361.44
Pathway:
Stem Cells; Proteases/Proteasome; Neuroscience
Purity:
0.9911
SMILES:
C[C@@H](C(=O)N[C@H]1c2ccccc2CCN(C1=O)C)NC(=O)[C@H](C(C)C)O
Target:
Beta Amyloid; Gamma-secretase

References

Mitani Y, et al. J Neurosci, 2012, 32(6), 2037-2050. Elvang AB, et al. J Neurochem, 2009, 110(5), 1377-1387.