GW 501516
Code | Size | Price |
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TAR-T6151-5mg | 5mg | £105.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T6151-1mL | 1 mL * 10 mM (in DMSO) | £109.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T6151-10mg | 10mg | £124.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T6151-25mg | 25mg | £161.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T6151-50mg | 50mg | £193.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T6151-100mg | 100mg | £243.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T6151-200mg | 200mg | £350.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T6151-500mg | 500mg | £498.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
GW501516 is a effective and highly specifc PPARβ/δ agonist (EC50: 1 nM), with 1000-fold selectivity over hPPARα/γ.
CAS:
317318-70-0
Formula:
C21H18F3NO3S2
Molecular Weight:
453.49
Pathway:
Metabolism; Autophagy; DNA Damage/DNA Repair
Purity:
0.9994
SMILES:
Cc1nc(sc1CSc1ccc(OCC(O)=O)c(C)c1)-c1ccc(cc1)C(F)(F)F
Target:
PPAR; Autophagy
References
Ren Q, Xie X, Zhao C, et al. 2, 2?, 4, 4?-Tetrabromodiphenyl Ether (PBDE 47) Selectively Stimulates Proatherogenic PPAR? Signatures in Human THP-1 Macrophages to Contribute to Foam Cell Formation. Chemical Research in Toxicology. 2022
Wei ZL, et al. A short and efficient synthesis of the pharmacological research tool GW501516 for the peroxisome proliferator-activated receptor delta. J Org Chem. 2003 Nov 14;68(23):9116-8.
Chen, W., Gao, R., Xie, X., Zheng, Z., Li, H., & Li, S. et al. (2015). A metabolomic study of the PPAR? agonist GW501516 for enhancing running endurance in Kunming mice.?Scientific Reports,?5(1). doi: 10.1038/srep09884
Han W, Wang N, Kong R, et al. Ligand-activated PPAR? expression promotes hepatocellular carcinoma progression by regulating the PI3K-AKT signaling pathway. Journal of Translational Medicine. 2022, 20(1): 1-14.