Gambogic Acid
| Code | Size | Price |
|---|
| TAR-T6185-1mL | 1 mL * 10 mM (in DMSO) | £135.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T6185-20mg | 20mg | £151.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Gambogic Acid ( EC50=0.78-1.64 uM) activates caspases. Gambogic Acid competitively suppresses Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1. The IC50s of Gambogic Acid for Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 are 1.47, 1.21, 2.02, 0.66, 1.06 and 0.79 uM, respectively.
CAS:
2752-65-0
Formula:
C38H44O8
Molecular Weight:
628.762
Pathway:
Autophagy; Apoptosis
Purity:
0.9838
SMILES:
CC(C)=CCC[C@@]1(C)Oc2c(CC=C(C)C)c3O[C@@]45[C@H]6C[C@@H](C=C4C(=O)c3c(O)c2C=C1)C(=O)[C@]5(CC=C(C)C(O)=O)OC6(C)C
Target:
BCL; Autophagy
References
Zhai D, et al. Mol Cancer Ther, 2008, 7(6), 1639-1646.
Zhang HZ, et al. Bioorg Med Chem, 2004, 12(2), 309-317.
Pandey MK, et al. Blood, 2007, 110(10), 3517-3525.
Yi T, et al. Cancer Res. 2008 Mar 15;68(6):1843-50.
Liu X, Hu Q, Wang W, et al. A protein-fragment complementation assay reveals that celastrol and gambogic acid suppress ER? mutants in breast cancer. Biochemical Pharmacology. 2021, 188: 114583.
Wang X, et al. Anticancer Agents Med Chem, 2012, 12(8), 1994-12000.