PP1

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TargetMol
Product Code: TAR-T6196
Supplier: TargetMol
CodeSizePrice
TAR-T6196-1mg1mg£98.00
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TAR-T6196-2mg2mg£109.00
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TAR-T6196-5mg5mg£136.00
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TAR-T6196-1mL1 mL * 10 mM (in DMSO)£140.00
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TAR-T6196-10mg10mg£168.00
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TAR-T6196-25mg25mg£241.00
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TAR-T6196-50mg50mg£309.00
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TAR-T6196-100mg100mg£446.00
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TAR-T6196-500mg500mg£914.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
PP1, a specific and effective Src inhibitor, is with IC50 for Lck/Fyn is 5 nM/ 6 nM, respectively.
CAS:
172889-26-8
Formula:
C16H19N5
Molecular Weight:
281.363
Pathway:
Tyrosine Kinase/Adaptors; JAK/STAT signaling; Apoptosis; Cytoskeletal Signaling; Angiogenesis
Purity:
0.9997
SMILES:
Cc1ccc(cc1)-c1nn(c2ncnc(N)c12)C(C)(C)C
Target:
Apoptosis; EGFR; Bcr-Abl; Src; c-Kit

References

Liu X, Yang J, Yang C, et al. Morphine promotes the?malignant biological behavior of?non-small cell lung cancer cells through?the?MOR/Src/mTOR pathway. Cancer cell International. 2021, 21(1): 1-14 Zhao Z, Xue F, Gu Y, et al. Crosstalk between the muscular estrogen receptor ? and BDNF/TrkB signaling alleviates metabolic syndrome via 7, 8-dihydroxyflavone in female mice. Molecular Metabolism. 2020: 101149. Liu X, Yang J, Yang C, et al. Morphine promotes the?malignant biological behavior of non-small cell lung cancer cells through the MOR/Src/mTOR pathway. Cancer Cell International. 2021, 21(1): 1-14 Zhao Z, Xue F, Gu Y, et al. Crosstalk between the muscular estrogen receptor ? and BDNF/TrkB signaling alleviates metabolic syndrome via 7, 8-dihydroxyflavone in female mice[J]. Molecular Metabolism. 2020: 101149. Hanke JH, et al. J Biol Chem, 1996, 271(2), 695-701. Tatton L, et al. J Biol Chem, 2003, 278(7), 4847-4853. Liu K, Hao Z, Zheng H, et al.Repurposing of rilpivirine for preventing platelet ?3 integrin-dependent thrombosis by targeting c-Src active autophosphorylation.Thrombosis Research.2023