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TargetMol
Product Code: TAR-T6199
Supplier: TargetMol
CodeSizePrice
TAR-T6199-2mg2mg£99.00
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Quantity:
TAR-T6199-5mg5mg£118.00
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Quantity:
TAR-T6199-1mL1 mL * 10 mM (in DMSO)£121.00
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Quantity:
TAR-T6199-10mg10mg£136.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T6199-25mg25mg£153.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T6199-50mg50mg£166.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T6199-100mg100mg£214.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
LEE011 is an orally available, and highly specific CDK4/6 inhibitor (IC50?10/39 nM).
CAS:
1211441-98-3
Formula:
C23H30N8O
Molecular Weight:
434.548
Pathway:
Angiogenesis; Tyrosine Kinase/Adaptors; Cell Cycle/Checkpoint
Purity:
0.9996
SMILES:
CN(C)C(=O)c1cc2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n1C1CCCC1
Target:
VEGFR; CDK

References

Ou J, Li H, Qiu P, et al. CDK9 modulates circadian clock by attenuating REV-ERB? activity[J]. Biochemical and biophysical research communications. 2019 Jun 11;513(4):967-973. Ou J, Li H, Qiu P, et al. CDK9 modulates circadian clock by attenuating REV-ERB? activity. Biochemical and Biophysical Research Communications. 2019 Jun 11;513(4):967-973 Rader J, et al. Clin Cancer Res. 2013, 19(22), 6173-6182.