Zibotentan

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TargetMol
Product Code: TAR-T6258
Supplier: TargetMol
CodeSizePrice
TAR-T6258-50mg50mgEnquire
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TAR-T6258-1mg1mg£99.00
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TAR-T6258-2mg2mg£112.00
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TAR-T6258-5mg5mg£138.00
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TAR-T6258-1mL1 mL * 10 mM (in DMSO)£146.00
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TAR-T6258-10mg10mg£189.00
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TAR-T6258-25mg25mg£309.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
Zibotentan (ZD4054) is a specific Endothelin (ET)A antagonist with IC50 of 21 nM, exhibiting no activity at ETB. Phase 3.
CAS:
186497-07-4
Formula:
C19H16N6O4S
Molecular Weight:
424.44
Pathway:
GPCR/G Protein; Apoptosis
Purity:
0.97
SMILES:
COc1nc(C)cnc1NS(=O)(=O)c1cccnc1-c1ccc(cc1)-c1nnco1
Target:
Apoptosis; Endothelin Receptor

References

Morris CD, et al. Br J Cancer, 2005, 92(12), 2148-2152. Rosan? L, et al. Cancer Res, 2007, 67(13), 6351-635 Rosan? L, et al. Mol Cancer Ther, 2007, 6(7), 22003-201 Rosan? L, et al. Exp Biol Med (Maywood), 2006, 231(6), 1132-113