RAF265

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TargetMol
Product Code: TAR-T6296
Supplier: TargetMol
CodeSizePrice
TAR-T6296-1mg1mg£102.00
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TAR-T6296-2mg2mg£116.00
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TAR-T6296-5mg5mg£142.00
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TAR-T6296-1mL1 mL * 10 mM (in DMSO)£152.00
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TAR-T6296-10mg10mg£191.00
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TAR-T6296-25mg25mg£295.00
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TAR-T6296-50mg50mg£438.00
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TAR-T6296-100mg100mg£611.00
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Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
RAF265 (CHIR-265) is a potent selective inhibitor of C-Raf/B-Raf/B-Raf V600E with IC50 of 3-60 nM, and exhibits potent inhibition on VEGFR2 phosphorylation with EC50 of 30 nM. Phase 2.
CAS:
927880-90-8
Formula:
C24H16F6N6O
Molecular Weight:
518.423
Pathway:
MAPK; Tyrosine Kinase/Adaptors; Autophagy; Apoptosis; Angiogenesis
Purity:
0.9918
SMILES:
Cn1c(Nc2ccc(cc2)C(F)(F)F)nc2cc(Oc3ccnc(c3)-c3nc(c[nH]3)C(F)(F)F)ccc12
Target:
Apoptosis; Raf; VEGFR; Autophagy

References

Chen J, et al. Cancer Res, 2011, 71(12), 4280-4291. AACR Meeting Abstracts 2008;2008:4876. Tseng JR, et al. Neoplasia, 2011, 13(3), 266-275. P?rez-Rivera AA, et al. Mutat Res, 2009, 672(1), 27-39 Zitzmann K, et al. Endocr Relat Cancer, 2011, 18(2), 277-285.