Bafetinib

Contact us
TargetMol
Product Code: TAR-T6311
Supplier: TargetMol
CodeSizePrice
TAR-T6311-1mg1mg£95.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T6311-2mg2mg£106.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T6311-5mg5mg£128.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T6311-1mL1 mL * 10 mM (in DMSO)£144.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T6311-10mg10mg£155.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T6311-25mg25mg£201.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T6311-50mg50mg£230.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T6311-100mg100mg£367.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T6311-200mg200mg£455.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

1 / 1
❮❯

Documents

Further Information

Bioactivity:
Bafetinib (INNO-406) is an effective and specific dual Bcr-Abl/Lyn inhibitor (IC50: 5.8/19 nM), and no inhibition of the phosphorylation of the T315I mutant and less effective to c-Kit and PDGFR.
CAS:
859212-16-1
Formula:
C30H31F3N8O
Molecular Weight:
576.62
Pathway:
Angiogenesis; Autophagy; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
Purity:
0.9968
SMILES:
CN(C)[C@H]1CCN(Cc2ccc(cc2C(F)(F)F)C(=O)Nc2ccc(C)c(Nc3nccc(n3)-c3cncnc3)c2)C1
Target:
Bcr-Abl; Src; Autophagy

References

Weng H, Xiong K P, Wang W, et al.Aspartoacylase suppresses prostate cancer progression by blocking LYN activation.Military Medical Research.2023, 10(1): 1-25. Jing Y, Dai X, Yang L, et al. STING couples with PI3K to regulate actin reorganization during BCR activation[J]. Science Advances. 2020, 6(17): eaax9455. Wu J, Nie Y, Wang J, et al. Fc? receptor?mediated phagocytosis pathway was involved in phagocytosis of mIgM+ B lymphocytes from largemouth bass (Micropterus salmoides). Journal of Fish Biology. 2022 Yokota A, et al. Blood. 2007, 109(1), 306-314. Kimura S, et al. Blood. 2005, 106(12), 3948-3954. Jing Y, Dai X, Yang L, et al. STING couples with PI3K to regulate actin reorganization during BCR activation. Science Advances. 2020, 6(17): eaax9455. Kamitsuji Y, et al. Cell Death Differ. 2008, 15(11), 1712-2172.