R547

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TargetMol
Product Code: TAR-T6312
Supplier: TargetMol
CodeSizePrice
TAR-T6312-1mg1mg£107.00
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TAR-T6312-2mg2mg£124.00
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TAR-T6312-5mg5mg£158.00
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TAR-T6312-1mL1 mL * 10 mM (in DMSO)£174.00
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TAR-T6312-10mg10mg£197.00
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TAR-T6312-25mg25mg£309.00
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TAR-T6312-50mg50mg£529.00
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TAR-T6312-100mg100mg£728.00
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TAR-T6312-500mg500mg£1,428.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
R547 is a potent ATP-competitive inhibitor of CDK1/2/4 with Ki of 2 nM/3 nM/1 nM. It is less potent to CDK7 and GSK3α/β, while inactive to other kinases. Phase 1.
CAS:
741713-40-6
Formula:
C18H21F2N5O4S
Molecular Weight:
441.45
Pathway:
PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors; Apoptosis; Cell Cycle/Checkpoint; Stem Cells
Purity:
0.9
SMILES:
COc1ccc(F)c(F)c1C(=O)c1cnc(NC2CCN(CC2)S(C)(=O)=O)nc1N
Target:
Apoptosis; GSK-3; PKA; CDK

References

Rodriguez A , et al. Mol Cancer Ther, 2006, 5(11), 2644-2658. Chu XJ, et al. J Med Chem, 2006, 49(22), 6549-6560. Berkofsky-Fessler W, et al. Mol Cancer Ther, 2009, 8(9), 2517-2525.