MLN8054

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TargetMol
Product Code: TAR-T6315
Supplier: TargetMol
CodeSizePrice
TAR-T6315-1mg1mg£109.00
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TAR-T6315-2mg2mg£124.00
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TAR-T6315-5mg5mg£149.00
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TAR-T6315-1mL1 mL * 10 mM (in DMSO)£152.00
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TAR-T6315-10mg10mg£217.00
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TAR-T6315-25mg25mg£336.00
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TAR-T6315-50mg50mg£466.00
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TAR-T6315-100mg100mg£646.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
MLN8054 is a potent and selective Aurora A kinase inhibitor with an IC50 of 4 nM.
CAS:
869363-13-3
Formula:
C25H15ClF2N4O2
Molecular Weight:
476.87
Pathway:
Stem Cells; Tyrosine Kinase/Adaptors; Chromatin/Epigenetic; Angiogenesis; Cell Cycle/Checkpoint; Metabolism
Purity:
0.9905
SMILES:
OC(=O)c1ccc(Nc2ncc3CN=C(c4cc(Cl)ccc4-c3n2)c2c(F)cccc2F)cc1
Target:
Casein Kinase; PKA; Src; Aurora Kinase

References

Li Y, Tang S, Shi X, et al.Metabolic classification suggests the GLUT1/ALDOB/G6PD axis as a therapeutic target in chemotherapy-resistant pancreatic cancer.Cell Reports Medicine.2023 Manfredi MG, et al. Proc Natl Acad Sci U S A, 2007, 104(10), 4106-4111. Huck JJ, et al. Mol Cancer Res, 2010, 8(3), 373-384. Moretti L, et al. Int J Radiat Oncol Biol Phys, 2011, 80(4), 1189-1197.