TargetMol

CHIR-124

Product Code:
 
TAR-T6350
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
❮❯

No additional charges, what you see is what you pay! *

CodeSizePrice
TAR-T6350-2mg2mg£108.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T6350-5mg5mg£130.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T6350-1mL1 mL * 10 mM (in DMSO)£134.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
Prices exclude any Taxes / VAT
How to order with us   Contact us
Stay in control of your spending. These prices have no additional charges, not even shipping!
* Rare exceptions are clearly labelled (only 0.14% of items!).
Multibuy discounts available! Contact us to find what you can save.
This product comes from: United States.
Typical lead time: 10-14 working days.
Contact us for more accurate information.
  • Further Information
  • Documents
  • References
  • Show All

Further Information

Bioactivity:
CHIR-124 is an effective Chk1 inhibitor (IC50: 0.3 nM). It has 2, 000-fold selectivity against Chk2, 500- to 5, 000-fold less activity against Cdc2 and CDK2/4.
CAS:
405168-58-3
Formula:
C23H22ClN5O
Molecular Weight:
419.91
Pathway:
Cell Cycle/Checkpoint; Angiogenesis; Stem Cells; Tyrosine Kinase/Adaptors; Apoptosis; PI3K/Akt/mTOR signaling
Purity:
0.9835
SMILES:
Clc1ccc2[nH]c(=O)c(-c3nc4ccccc4[nH]3)c(N[C@@H]3CN4CCC3CC4)c2c1
Target:
Apoptosis; GSK-3; FLT; Chk; PDGFR; Src

References

Tse AN, et al, Clin Cancer Res, 2007, 13(2 Pt 1), 591-602. Dai Y, et al, Clin Cancer Res, 2010, 16(2), 376-383