A 922500
Code | Size | Price |
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TAR-T6365-1mg | 1mg | £107.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T6365-2mg | 2mg | £121.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T6365-5mg | 5mg | £148.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T6365-1mL | 1 mL * 10 mM (in DMSO) | £160.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T6365-10mg | 10mg | £185.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T6365-25mg | 25mg | £287.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T6365-50mg | 50mg | £434.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T6365-100mg | 100mg | £606.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
A922500 is an inhibitor for human and mouse DGAT-1 with IC50 of 7 nM and 24 nM, respectively, good selectivity over related acyltransferases, hERG, and a panel of anti-targets.
CAS:
959122-11-3
Formula:
C26H24N2O4
Molecular Weight:
428.488
Pathway:
Metabolism
Purity:
0.9734
SMILES:
OC(=O)[C@@H]1CCC[C@H]1C(=O)c1ccc(cc1)-c1ccc(NC(=O)Nc2ccccc2)cc1
Target:
Acyltransferase; Transferase
References
Wang W, Qu Y, Wang X, et al.Genetic variety of ORF3a shapes SARS?CoV?2 fitness through modulation of lipid droplet.Journal of Medical Virology.2023
Zhao G, et al. J Med Chem. 2008, 51(3), 380-383.
King AJ et al. J Pharmacol Exp Ther. 2009, 330(2), 526-531.
King AJ, et al. Eur J Pharmacol. 2010, 637(1-3), 155-161.
Karagiannis F, Masouleh S K, Wunderling K, et al. Lipid-Droplet Formation Drives Pathogenic Group 2 Innate Lymphoid Cells in Airway Inflammation. Immunity. 2020, 52(4): 620-634. e6.
Masouleh S K. Lipid droplet formation drives pathogenic ILC2 responses in airway inflammation .
Karagiannis F, Masouleh S K, Wunderling K, et al. Lipid-Droplet Formation Drives Pathogenic Group 2 Innate Lymphoid Cells in Airway Inflammation[J]. Immunity. 2020, 52(4): 620-634. e6.
Masouleh S K. Lipid droplet formation drives pathogenic ILC2 responses in airway inflammation. Immunity. 2020