BV6

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TargetMol
Product Code: TAR-T6428
Supplier: TargetMol
CodeSizePrice
TAR-T6428-1mg1mg£106.00
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TAR-T6428-2mg2mg£120.00
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TAR-T6428-5mg5mg£148.00
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TAR-T6428-10mg10mg£195.00
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TAR-T6428-1mL1 mL * 10 mM (in DMSO)£230.00
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TAR-T6428-25mg25mg£325.00
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TAR-T6428-50mg50mg£550.00
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TAR-T6428-100mg100mg£755.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
BV6 is an antagonist of c-IAP1 and XIAP, members of the inhibitors of apoptosis (IAP) family.
CAS:
1001600-56-1
Formula:
C72H100N10O10
Molecular Weight:
1265.652
Pathway:
Apoptosis
Purity:
0.9946
SMILES:
CC(O)=O.CN[C@@H](C)C(=O)N[C@@H](C1CCCCC1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(c1ccccc1)c1ccccc1)C(=O)NCCCCCCNC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](NC(=O)[C@H](C)NC)C1CCCCC1)C(c1ccccc1)c1ccccc1
Target:
IAP

References

Li Y, Lee H H, Jiang V C, et al.Potentiation of apoptosis in drug-resistant mantle cell lymphoma cells by MCL-1 inhibitor involves downregulation of inhibitor of apoptosis proteins.Cell Death & Disease.2023, 14(11): 714. Li W, et al. J Thorac Oncol. 2011, 6(11), 1801-1809. Uegaki T, et al. Inhibitor of apoptosis proteins (IAPs) may be effective therapeutic targets for treating endometriosis. Hum Reprod. 2015 Jan;30(1):149-58. Rettinger E, et al. Front Pediatr. 2014, 18, 2:75. M?ller-Sienerth N, et al. PLoS One. 2011, 6(6), e21556 Xu H, Tang Z, Zuo Y, et al. Molecular dynamics simulation revealed the intrinsic conformational change of cellular inhibitor of apoptosis protein-1[J]. Journal of Biomolecular Structure and Dynamics. 2020, 38(4): 975-984. Xu H, Tang Z, Zuo Y, et al. Molecular dynamics simulation revealed the intrinsic conformational change of cellular inhibitor of apoptosis protein-1. Journal of Biomolecular Structure and Dynamics. 2020, 38(4): 975-984