Cilomilast

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TargetMol
Product Code: TAR-T6445
Supplier: TargetMol
CodeSizePrice
TAR-T6445-1mg1mg£97.00
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TAR-T6445-2mg2mg£107.00
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TAR-T6445-5mg5mg£136.00
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TAR-T6445-1mL1 mL * 10 mM (in DMSO)£141.00
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TAR-T6445-10mg10mg£189.00
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TAR-T6445-25mg25mg£286.00
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TAR-T6445-50mg50mg£454.00
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TAR-T6445-100mg100mg£631.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
Cilomilast is a potent PDE4 inhibitor with IC50 of about 110 nM, has anti-inflammatory activity and low central nervous system activity. Phase 3.
CAS:
153259-65-5
Formula:
C20H25NO4
Molecular Weight:
343.423
Pathway:
Metabolism
Purity:
0.98
SMILES:
COc1ccc(cc1OC1CCCC1)[C@]1(CC[C@@H](CC1)C(O)=O)C#N
Target:
PDE

References

Kobayashi M, et al. Int Immunopharmacol. 2011, 11(6), 732-739. Sadrai Z, et al. Invest Ophthalmol Vis Sci. 2012. Pace E, et al. Cell Immunol. 2011, 268(1), 47-53. Barnette MS, et al. J Pharmacol Exp Ther. 1998, 284(1), 420-426. Griswold DE,et al. J Pharmacol Exp Ther. 1998, 287(2),705-711.