Droxinostat

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TargetMol
Product Code: TAR-T6481
Supplier: TargetMol
CodeSizePrice
TAR-T6481-2mg2mg£95.00
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TAR-T6481-5mg5mg£107.00
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TAR-T6481-1mL1 mL * 10 mM (in DMSO)£108.00
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TAR-T6481-10mg10mg£140.00
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TAR-T6481-25mg25mg£219.00
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TAR-T6481-50mg50mg£294.00
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TAR-T6481-100mg100mg£402.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
Droxinostat is a selective inhibitor of HDAC, mostly for HDACs 6 and 8 with IC50 of 2.47 μM and 1.46 μM, greater than 8-fold selective against HDAC3 and no inhibition to HDAC1, 2, 4, 5, 7, 9, and 10.
CAS:
99873-43-5
Formula:
C11H14ClNO3
Molecular Weight:
243.69
Pathway:
DNA Damage/DNA Repair; Chromatin/Epigenetic; Apoptosis
Purity:
0.9976
SMILES:
Cc1cc(Cl)ccc1OCCCC(=O)NO
Target:
Apoptosis; HDAC

References

Schimmer AD, et al. Cancer Res, 2006, 66(4), 2367-2375. Bijangi-Vishehsaraei K, et al. Mol Cell Biochem, 2010, 342(1-2), 133-142. Wood TE, et al. Mol Cancer Ther, 2010, 9(1), 246-256. Mawji IA, et al. J Natl Cancer Inst, 2007, 99(10), 811-822.