NU6027

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TargetMol
Product Code: TAR-T6612
Supplier: TargetMol
CodeSizePrice
TAR-T6612-2mg2mg£101.00
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TAR-T6612-5mg5mg£119.00
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Quantity:
TAR-T6612-10mg10mg£152.00
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TAR-T6612-25mg25mg£237.00
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Quantity:
TAR-T6612-50mg50mg£334.00
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Quantity:
TAR-T6612-100mg100mg£464.00
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Quantity:
TAR-T6612-500mg500mg£946.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
NU6027 is a potent ATR/CDK inhibitor, inhibits CDK1/2, ATR and DNA-PK with Ki of 2.5 μM/1.3 μM, 0.4 μM and 2.2 μM, enter cells more readily than the 6-aminopurine-based inhibitors.
CAS:
220036-08-8
Formula:
C11H17N5O2
Molecular Weight:
251.29
Pathway:
PI3K/Akt/mTOR signaling; DNA Damage/DNA Repair; Cell Cycle/Checkpoint
Purity:
0.9985
SMILES:
Nc1nc(N)c(N=O)c(OCC2CCCCC2)n1
Target:
ATM/ATR; DNA-PK; CDK

References

Peasland A, et al. Br J Cancer, 2011, 105(3), 372-381. Arris CE, et al. J Med Chem, 2000, 43(15), 2797-2804. Charrier JD, et al. J Med Chem, 2011, 54(7), 2320-2330. Sultana R, et al. PLoS One, 2013, 8(2), e57098.