Refametinib

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TargetMol
Product Code: TAR-T6636
Supplier: TargetMol
CodeSizePrice
TAR-T6636-1mg1mg£97.00
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TAR-T6636-2mg2mg£108.00
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TAR-T6636-5mg5mg£129.00
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TAR-T6636-1mL1 mL * 10 mM (in DMSO)£149.00
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TAR-T6636-10mg10mg£160.00
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TAR-T6636-25mg25mg£228.00
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TAR-T6636-50mg50mg£309.00
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TAR-T6636-100mg100mg£429.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
Refametinib (RDEA119, Bay 86-9766) is an effective, ATP non-competitive and specific inhibitor of MEK1/2 (IC50: 19/47 nM).
CAS:
923032-37-5
Formula:
C19H20F3IN2O5S
Molecular Weight:
572.34
Pathway:
MAPK
Purity:
1
SMILES:
Fc1cc(OC)c(NS(=O)(=O)C2(CC2)C[C@H](O)CO)c(Nc2ccc(I)cc2F)c1F
Target:
MEK

References

Liu D, et al, Int J Cancer, 2010, 127(12), 2965-2973. Li Y, He Y, Peng J, et al. Mutant Kras co-opts a proto-oncogenic enhancer network in inflammation-induced metaplastic progenitor cells to initiate pancreatic cancer[J]. Nature Cancer. 2020: 1-17. Iverson C, et al, Cancer Res, 2009, 69(17), 6839-6847.