WZ-3146

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TargetMol
Product Code: TAR-T6733
Supplier: TargetMol
CodeSizePrice
TAR-T6733-1mg1mg£109.00
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TAR-T6733-2mg2mg£125.00
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TAR-T6733-5mg5mg£149.00
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TAR-T6733-1mL1 mL * 10 mM (in DMSO)£157.00
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TAR-T6733-10mg10mg£222.00
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TAR-T6733-25mg25mg£340.00
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TAR-T6733-50mg50mg£502.00
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TAR-T6733-100mg100mg£687.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
WZ3146 is a mutant-selective irreversible inhibitor of EGFR(L858R) and EGFR(E746_A750) with IC50 of 2 nM and 2 nM; does not inhibit ERBB2 phosphorylation (T798I).
CAS:
1214265-56-1
Formula:
C24H25ClN6O2
Molecular Weight:
464.95
Pathway:
Tyrosine Kinase/Adaptors; Angiogenesis; JAK/STAT signaling
Purity:
0.9895
SMILES:
CN1CCN(CC1)c1ccc(Nc2ncc(Cl)c(Oc3cccc(NC(=O)C=C)c3)n2)cc1
Target:
EGFR

References

Zhou W, et al. Nature, 2009, 462(7276), 1070-1074.