A-1155463

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TargetMol
Product Code: TAR-T6748
Supplier: TargetMol
CodeSizePrice
TAR-T6748-50mg50mgEnquire
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TAR-T6748-1mg1mg£101.00
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TAR-T6748-2mg2mg£114.00
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TAR-T6748-5mg5mg£142.00
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TAR-T6748-1mL1 mL * 10 mM (in DMSO)£177.00
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TAR-T6748-10mg10mg£189.00
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TAR-T6748-25mg25mg£291.00
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Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
A-1155463, a highly potent and selective BCL-XL inhibitor, shows picomolar binding affinity to BCL-XL, and >1000-fold weaker binding to BCL-2 and related proteins BCL-W(Ki=19 nM) and MCL-1(Ki>440 nM).
CAS:
1235034-55-5
Formula:
C35H32FN5O4S2
Molecular Weight:
669.79
Pathway:
Apoptosis
Purity:
0.99
SMILES:
CN(C)CC#Cc1ccc(OCCCc2sc(nc2C(O)=O)N2CCc3cccc(C(=O)Nc4nc5ccccc5s4)c3C2)c(F)c1
Target:
BCL

References

Haichao Zhang, et al. Molecular Cancer. 2015, 14(1):1-9. Tao ZF, et al. ACS Med Chem Lett. 2014, 5(10):1088-93. Devin J, Ca?eque T, Lin Y L, et al. Targeting cellular iron homeostasis with ironomycin in diffuse large B cell lymphoma. Cancer Research. 2022 Devin J, Ca?eque T, Lin Y L, et al. Targeting cellular iron homeostasis with ironomycin in diffuse large B cell lymphomaTargeting cellular iron homeostasis with ironomycin in DLBCL. Cancer Research. 2022 Leverson JD, et al. Sci Transl Med. 2015, 7(279):279ra40.