BIO-acetoxime

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TargetMol
Product Code: TAR-T6787
Supplier: TargetMol
CodeSizePrice
TAR-T6787-1mg1mg£98.00
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TAR-T6787-2mg2mg£109.00
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TAR-T6787-1mL1 mL * 10 mM (in DMSO)£128.00
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TAR-T6787-5mg5mg£128.00
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TAR-T6787-10mg10mg£163.00
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TAR-T6787-25mg25mg£282.00
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TAR-T6787-50mg50mg£389.00
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TAR-T6787-100mg100mg£544.00
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Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
BIO-acetoxime is a potent dual GSK3α/β inhibitor with IC50 of 10 nM, >240-fold selectivity over CDK5/p25, CDK2/cyclin A and CDK1/cyclin B.
CAS:
667463-85-6
Formula:
C18H12BrN3O3
Molecular Weight:
398.216
Pathway:
Apoptosis; PI3K/Akt/mTOR signaling; Stem Cells; Microbiology/Virology
Purity:
0.9728
SMILES:
CC(=O)ON=C1/C(/Nc2ccccc/12)=C1/C(=O)Nc2cc(Br)ccc12
Target:
Apoptosis; GSK-3; HSV

References

Polychronopoulos P, et al. J Med Chem. 2004, 47(4), 935-946. Hsu MJ, et al. Arch Virol. 2013, 158(6), 1287-1296. Khan KA, et al. Mol Cell Biol. 2015, 35(17), 3029-3043. Duffy DJ, et al. Mol Cancer Ther. 2014, 13(2), 454-467.