FRAX486 HCL(1232030-35-1 free base)

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TargetMol
Product Code: TAR-T6840L
Supplier: TargetMol
CodeSizePrice
TAR-T6840L-1mg1mg£100.00
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TAR-T6840L-2mg2mg£111.00
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TAR-T6840L-5mg5mg£118.00
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TAR-T6840L-10mg10mg£148.00
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Quantity:
TAR-T6840L-1mL1 mL * 10 mM (in DMSO)£160.00
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TAR-T6840L-25mg25mg£211.00
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TAR-T6840L-50mg50mg£281.00
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TAR-T6840L-100mg100mg£386.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
FRAX486 HCL is a potent p21-activated kinase (PAK) inhibitor with IC50 values of 14, 33, 39 and 575 nM for PAK1, PAK2, PAK3 and PAK4 respectively.
CAS:
T6840L
Formula:
C25H24Cl3FN6O
Molecular Weight:
549.86
Pathway:
Cytoskeletal Signaling
Purity:
0.9982
SMILES:
FC1=CC(NC2=NC=C3C(N(C(C(C4=CC=C(C=C4Cl)Cl)=C3)=O)CC)=N2)=CC=C1N5CCNCC5.[H]Cl
Target:
PAK

References

Dolan BM, et al. Proc Natl Acad Sci U S A. 2013, 110(14):5671-6. Hayashi-Takagi A, et al. Proc Natl Acad Sci U S A. 2014, 111(17):6461-6. Wang Y, et al. PLoS One. 2016, 11(4):e20153312.