ON123300

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TargetMol
Product Code: TAR-T6920
Supplier: TargetMol
CodeSizePrice
TAR-T6920-1mg1mg£109.00
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TAR-T6920-2mg2mg£127.00
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TAR-T6920-1mL1 mL * 10 mM (in DMSO)£152.00
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TAR-T6920-5mg5mg£152.00
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Quantity:
TAR-T6920-10mg10mg£213.00
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TAR-T6920-25mg25mg£358.00
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TAR-T6920-50mg50mg£500.00
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TAR-T6920-100mg100mg£691.00
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TAR-T6920-500mg500mg£1,340.00
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Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
ON123300 is a potent and multi-targeted kinase inhibitor for CDK4/Ark5/PDGFRβ/FGFR1/RET/Fyn (IC50: 3.9/5/26/26/9.2/11 nM).
CAS:
1357470-29-1
Formula:
C24H27N7O
Molecular Weight:
429.528
Pathway:
JAK/STAT signaling; Apoptosis; PI3K/Akt/mTOR signaling; Chromatin/Epigenetic; Tyrosine Kinase/Adaptors; Angiogenesis; Stem Cells; Cell Cycle/Checkpoint
Purity:
0.9984
SMILES:
CN1CCN(CC1)c1ccc(Nc2ncc3cc(C#N)c(=O)n(C4CCCC4)c3n2)cc1
Target:
FGFR; c-RET; JAK; CDK; PDGFR; Src; AMPK

References

Zhang X, et al. Mol Cancer Ther. 2014 May;13(5):1105-16. Divakar SK, et al .Leukemia. 2016 Jan;30(1):86-93. Perumal D, et al. Cancer Res. 2016 Mar 1;76(5):1225-36.