PX-478
Code | Size | Price |
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TAR-T6961-2mg | 2mg | £109.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T6961-1mL | 1 mL * 10 mM (in DMSO) | £136.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T6961-5mg | 5mg | £136.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T6961-10mg | 10mg | £182.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T6961-25mg | 25mg | £243.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T6961-50mg | 50mg | £304.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T6961-100mg | 100mg | £438.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
PX-478 2HCl is an orally active, and selective inhibitor of hypoxia-inducible factor-1α (HIF-1α).
CAS:
685898-44-6
Formula:
C13H20Cl4N2O3
Molecular Weight:
394.11
Pathway:
Chromatin/Epigenetic; Autophagy; Metabolism; Angiogenesis
Purity:
0.9793
SMILES:
Cl.Cl.N[C@@H](Cc1ccc(cc1)[N+]([O-])(CCCl)CCCl)C(O)=O
Target:
HIF/HIF Prolyl-Hydroxylase; HIF; Autophagy
References
Sun K, et al. Mol Cell Biol. 2013, (5), 904-917.
Koh MY, et al. Mol Cancer Ther. 2008, 7(1), 90-100.
Palayoor ST, et al. Int J Cancer. 2008, 123(10), 2430-2437.
Welsh S, et al. Mol Cancer Ther. 2004, 3(3), 233-244.
Chang L L, Lu P H, Yang W, et al. AKR1C1 promotes non-small cell lung cancer proliferation via crosstalk between HIF-1? and metabolic reprogramming. Translational Oncology. 2022, 20: 101421
Liu R, Tian Y, Wang J, et al.Visible light?initiated radical 1,3-difunctionalization of ?, ?-unsaturated ketones.Science Advances.2022, 8(49): eabq8596.